The hemoglobin profile and erythroleukemia
نویسندگان
چکیده
منابع مشابه
On the presence of hemoglobin in erythroleukemia cells.
E ACUTE LEUKEMIA CELL represents a growing malignant element arising in the hematopoietic tissue. In contrast to the normal blood cell development, differentiation is absent or defective, which gives the cell a general “blastlike” appearance, i. e., a basophilic cytoplasm and a big, irregularly rounded nucleus containing prominent nucleoli. Cytochemically, the acute leukemia cell is characteriz...
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Hemoglobin and ferritin iron content have been followed during differentiation in tissue cultures of murine erythroleukemia cells (MELC) using the techniques of Mössbauer spectroscopy and electron microscopy. In undifferentiated cells grown without DMSO, only iron stored in ferritin was detected. The amount of iron in a cell grown in the presence of iron citrate is approximately 1.2 X 10(-14) g...
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Background: Diabetes mellitus is a chronic metabolic disorder characterized by defect in insulin secretion and action resulting in hyperglycemia. Diabetic patients have deranged body metabolisms particularly for lipids which may result in abnormal levels of serum levels of lipids. Methods: The aim of this study is to find any possible correlation between the the glycosylated hemoglobin and the...
متن کاملPeptide nucleic acids targeting β-globin mRNAs selectively inhibit hemoglobin production in murine erythroleukemia cells
In the treatment of hemoglobinopathies, amending altered hemoglobins and/or globins produced in excess is an important part of therapeutic strategies and the selective inhibition of globin production may be clinically beneficial. Therefore the development of drug-based methods for the selective inhibition of globin accumulation is required. In this study, we employed peptide nucleic acids (PNAs...
متن کاملSurface antigenic profile and globin phenotype of two new human erythroleukemia lines: characterization and interpretations.
Detailed characterization of the composite phenotype of two newly established erythroleukemia lines (OCIM1, OCIM2) shows that these lines share many of their erythroid markers (ie, surface antigens and globin program) as well as several of their nonerythroid properties (myeloid/monocytic/megakaryocytic) with the two known erythroleukemia lines (K562, HEL). In addition, each displays novel and i...
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ژورنال
عنوان ژورنال: Cancer
سال: 1970
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197010)26:4<904::aid-cncr2820260425>3.0.co;2-o